Uniques

A unique belongs to no set. It brings one effect nothing else has, and keeps it while worn.

Uniques are never below Rare, and never in the floor's market. They come from bosses, elites, Wardens, chests and the merchant: a depth boss's pick of three holds one 25% of the time, the merchant's first piece is one 15% of the time, a chest's 10%, an elite's or Warden's drop 5%. A unique takes a slot a set piece could fill, so each one is a trade.

From The Gilt Cellars

Unique	Slot	Effect
The Tallyman's Ledger	Neck	Kills pay 50% more gold.Every kill pays half again as much gold, on top of gold find.
Rat King's Crown	Head	Minions and summoned enemies die to any damage.Minions and summoned enemies (Gildlings, and the helpers a boss calls with Summon; not the Tallyman's collectors) die to any hit that deals damage.
Ember Heart	Ring	Your burn never fades.Burn on enemies no longer drops by 1 each turn: it only grows.
Pilgrim's Sandals	Feet	Gain 1 gem at the end of every floor.Clearing a floor's last fight pays 2 gems instead of 1.
Merchant's Purse	Neck	Market refreshes cost 30% less.The floor market's refresh costs 30% less.
Gambler's Die	Ring	Crits have a 25% chance to deal double crit damage.Each crit has a 25% chance to count your crit damage twice.
Bramble Crown	Head	Your thorns also apply 1 bleed.Each time your thorns hurt an enemy, it also gains 1 bleed.
Hoarder's Sack	Legs	Your loot stash holds 4 more items.Your loot stash holds 12 pieces instead of 8.
Last Stand Plate	Chest	Below 30% health: +50% power and +50% armor.While you have lost more than 70% of your health, you have +50% power and +50% armor.
Coin Mimic's Tongue	Neck	Selling pays 50% more, up to 75% of the price.Selling pays 60% of the price instead of 40% (75% for Pip with Fence, the most selling can pay).

From The Drowned Reliquary

Unique	Slot	Effect
Mother Brine's Pearl	Ring	Regenerate 4% health each turn.At the start of each of your turns you heal 4% of your maximum health.
Wisp Lantern	Ring	The first enemy to attack you each turn is blinded first.Each enemy turn, the first enemy that goes to attack you is blinded first, so that attack has a 40% chance to miss.
Ossuary Bell	Neck	Each kill applies 1 curse to every living enemy.Each kill puts 1 curse on every enemy still standing (10 at most). Each curse makes it take 4% more damage.
Shatterglass Blade	Weapon	Crits strip all armor from the target.A crit removes all of the target's armor before the strike's damage is counted.
Twinned Fangs	Weapon	Extra strikes, a lighter hand.
Moonlit Circlet	Head	Casting a skill heals 6% health.Each time you cast a skill you heal 6% of your maximum health.
Anvil Plate	Chest	Heavy enough to stop anything.
Tidecaller's Trident	Weapon	Strikes on a full-health enemy deal +100% damage.A strike on an enemy that is still at full health deals double.
Frostbite Greaves	Legs	Enemies that hit you gain 1 chill.An enemy whose blow lands on you gains 1 chill, so three blows freeze it.
Vampire's Kiss	Ring	Kills heal 12% health.Each kill heals 12% of your maximum health.

From The Hoard Heart

Unique	Slot	Effect
Avarax's Tooth	Weapon	+1% damage for every 50 gold you carry, up to +60%.Everything you deal grows by 1% for every 50 gold you carry, up to +60% at 3,000 gold.
Empty Crown	Head	+1 strike while at full health.While you are at full health, you make one more strike with every ATTACK.
Gargoyle's Heart	Chest	Every 3rd turn your armor refills completely.On turns 3, 6, 9 and so on, all the armor you have lost comes back.
Drakeling Scale Boots	Feet	You are immune to burn.Enemy burns never land on you, and any burn you carry is put out.
Haunted Greaves	Legs	Guarding restores twice as much armor.GUARD restores 80% of your armor instead of 40% (all of it for Brannoch with Stalwart).
Leech Lord's Mantle	Chest	Healing past full health becomes armor.Healing that would go past full health restores lost armor instead.
Starfall Staff	Weapon	Every 4th strike calls a star: 150% arcana to every enemy.Every 4th strike you land in a battle calls a star: every enemy takes 150% of your arcana, ignoring armor.
Gilded Hourglass	Neck	Enemies skip their first turn of every battle.In every battle the enemies do nothing on the first turn.
Cursed Coin	Ring	You take 10% more damage.Every hit on you deals 10% more.
Watcher's Eye	Neck	Your strikes always crit stunned, frozen or blinded enemies.Your strikes always crit an enemy that is stunned, frozen or blinded.

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Written from the game's own rules, version 2.9.4. Spotted something wrong? Tell us on Discord.